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BioXCell熱銷產(chǎn)品--RecombiMAb anti-mouse CTLA-4 (CD152) (LALA-PG)

更新時(shí)間：2024-01-23   點(diǎn)擊次數(shù)：283次

BioXCell熱銷產(chǎn)品--RecombiMAb anti-mouse CTLA-4 (CD152) (LALA-PG)

 

產(chǎn)品描述：

9D9-CP008單克隆抗體是原始9D9單克隆抗體的重組嵌合型抗體?？勺兘Y(jié)構(gòu)域序列與原始9D9克隆號相同，但是恒定區(qū)序列已經(jīng)從小鼠IgG2b變?yōu)樾∈驣gG2a。9D9-CP008單克隆抗體在Fc片段中也含有LALA-PG突變，使其無法與內(nèi)源性Fcγ受體結(jié)合。

 

9D9-CP008單克隆抗體能與小鼠CTLA-4(細(xì)胞毒性T淋巴細(xì)胞抗原-4)反應(yīng)，CTLA-4也稱為CD152。CTLA-4是一種33 kDa的細(xì)胞表面受體，由屬于免疫球蛋白超家族CD28家族的Ctla4基因編碼。CTLA-4在活化的T淋巴細(xì)胞和B淋巴細(xì)胞上表達(dá)。CTLA-4在結(jié)構(gòu)上類似于T細(xì)胞共刺激蛋白CD28，兩種分子都與B7家族成員B7-1 (CD80)和B7-2 (CD86)結(jié)合。在與配體結(jié)合時(shí)，CTLA-4負(fù)調(diào)節(jié)細(xì)胞介導(dǎo)的免疫反應(yīng)。CTLA-4在誘導(dǎo)和/或維持免疫耐受、胸腺細(xì)胞發(fā)育和保護(hù)性免疫調(diào)節(jié)中起作用。CTLA-4在免疫下調(diào)中的關(guān)鍵作用已經(jīng)在CTLA-4缺陷小鼠中得到證實(shí)，這些小鼠在3-5周齡時(shí)由于淋巴增生性疾病的發(fā)展而死亡。CTLA-4目前是腫瘤免疫治療中的熱門免疫檢查點(diǎn)靶點(diǎn)之一。

 

產(chǎn)品詳情：

產(chǎn)品名稱

RecombiMAb anti-mouse CTLA-4 (CD152) (LALA-PG)/欣博盛生物

產(chǎn)品貨號

CP008

產(chǎn)品規(guī)格

1mg

反應(yīng)種屬

Mouse

克隆號

9D9-CP008

同種型

Mouse IgG2b(switched from mouse IgG2a)

免疫原

Not available or unknown

實(shí)驗(yàn)應(yīng)用

in vivo CTLA-4 neutralization*

Western blot*

*Reported for the original mouse IgG2b 9D9 antibody

產(chǎn)品形式

PBS, pH 7.0,Contains no stabilizers or preservatives

純度

>95%, Determined by SDS-PAGE

聚合

<5%, Determined by SEC

無菌處理

0.2 µm filtration

純化方式

Protein A

分子量

150 kDa

小鼠病原檢測

Ectromelia/Mousepox Virus: Negative

Hantavirus: Negative

K Virus: Negative

Lactate Dehydrogenase-Elevating Virus: Negative

Lymphocytic Choriomeningitis virus: Negative

Mouse Adenovirus: Negative

Mouse Cytomegalovirus: Negative

Mouse Hepatitis Virus: Negative

Mouse Minute Virus: Negative

Mouse Norovirus: Negative

Mouse Parvovirus: Negative

Mouse Rotavirus: Negative

Mycoplasma Pulmonis: Negative

Pneumonia Virus of Mice: Negative

Polyoma Virus: Negative

Reovirus Screen: Negative

Sendai Virus: Negative

Theiler’s Murine Encephalomyelitis: Negative

保存條件

抗體原液保存在4°C，不能冷凍保存。

推薦抗體稀釋液

InVivoPure pH 7.0 Dilution Buffer（貨號IP0070）

 

該產(chǎn)品自上市已被多篇SCI文獻(xiàn)引用，品質(zhì)有保證，以下是部分已發(fā)表的文獻(xiàn)引用：

應(yīng)用

文章

體內(nèi)CTLA-4中和

(in vivo CTLA-4 

neutralization)

1. Dai, M., et al. (2015). 'Curing mice with large tumors by locally 

delivering combinations of immunomodulatory antibodies' 

Clin Cancer Res 21(5): 1127-1138.

2. Zippelius, A., et al. (2015). 'Induced PD-L1 expression mediates 

acquired resistance to agonistic anti-CD40 treatment' Cancer Immunol 

Res 3(3): 236-244.

3. Redmond, W. L., et al. (2014). 'Combined targeting of costimulatory 

(OX40) and coinhibitory (CTLA-4) pathways elicits potent effector T 

cells capable of driving robust antitumor immunity' Cancer Immunol 

Res 2(2): 142-153.

4. Condamine, T., et al. (2014). 'ER stress regulates myeloid-derived 

suppressor cell fate through TRAIL-R-mediated apoptosis' J Clin Invest 

124(6): 2626-2639.

5. Muller, P., et al. (2014). 'Microtubule-depolymerizing agents used in 

antibody-drug conjugates induce antitumor immunity by stimulation of 

dendritic cells' Cancer Immunol Res 2(8): 741-755.

6. Bulliard, Y., et al. (2013). 'Activating Fc gamma receptors contribute 

to the antitumor activities of immunoregulatory receptor-targeting 

antibodies' J Exp Med 210(9): 1685-1693.

 

 

 

BioXCell熱銷產(chǎn)品--RecombiMAb anti-mouse CTLA-4 (CD152) (LALA-PG)

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